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Projects In Knowledge®
is pleased to introduce the Living Medical Textbook™ — an interactive resource that builds a knowledge base through a series of educational modules.

In every chapter of a Living Medical Textbook™
you will find supportive multimedia hyperlinks to illustrations, videos, journal articles, glossary terms, online textbooks, and other resources which enhance the relevant
issues in the text.

As a "living" resource,
the educational content will be periodically updated. Each edition of Living Medical Textbook
offers free AMA PRA Category
1 Credits

Type 2 Diabetes Milletus in Practice
Newly Updated Chapter
iPhone iPad

Chapter 1 - Goals of Treatment for
Type 2 Diabetes Mellitus
Last Reviewed: September 28, 2010

Comprehensive care of patients with type 2 diabetes mellitus (T2DM) includes aggressive management of this disease. It is critically important for patients with T2DM to meet target goals for glycemic control and long-term goals to prevent complications, such as hypertension, dyslipidemia, kidney failure, etc. In this first chapter of the Living Medical Textbook™: Diabetes Edition: Type 2 Diabetes Mellitus in Practice, Alan J. Garber, MD, PhD, reviews both short- and long-term goals of care for patients with T2DM based on current guidelines and evidence-based medicine. Preventing chronic complications of T2DM is vital in reducing the morbidity and mortality associated with this serious disease.
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Chapter 2 - DPP-4 and Its Inhibitors in
Type 2 Diabetes
Newly Updated Chapter
Release Date: October 2010

What is the function of DPP-4 and how does it affect glucose levels? Why is it a relevant therapeutic target in T2DM? How do DPP4 inhibitors help reduce hyperglycemia in T2DM? Janet B. McGill, MD, answers these questions by explaining the science behind DPP-4 and its inhibitors.
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Chapter 3 - DPP-4 Inhibitors:
Clinical Data and Practices
Release Date: October 2010

Two FDA-approved formulations of dipeptidyl peptidase 4 (DPP-4) inhibitors are currently available. In the third chapter of the Living Medical Textbook™: Diabetes Edition: Type 2 Diabetes Mellitus in Practice, Janet B. McGill, MD, reviews current data on their efficacy and safety. In addition, she provides practical information on how to best put them to use, identifying their most appropriate role in combination regimens, and explaining how to dose them and manage side effects.


Chapter 4 - SGLT2 and Its Inhibitors in
Type 2 Diabetes
Release Date: November 2010

What is the function of sodium glucose cotransporter 2 (SGLT2) and how does it affect glucose levels? Why is it a relevant therapeutic target in type 2 diabetes mellitus (T2DM)? Do SGLT2 inhibitors in development have potential to reduce hyperglycemia in T2DM? In the fourth chapter of the Living Medical Textbook™: Diabetes Edition: Type 2 Diabetes Mellitus in Practice, Vivian Fonseca, MD, provides a detailed explanation of the science behind this emerging class of therapies for T2DM.


Chapter 5 - SGLT2 Inhibitors:
Clinical Data and Emerging Uses
Release Date: December 2010

Sodium glucose cotransporter 2 (SGLT2) inhibitors are emerging as an exciting new class of therapies for type 2 diabetes mellitus (T2DM), with four agents currently in development. In this fifth chapter of the Living Medical Textbook™: Diabetes Edition: Type 2 Diabetes Mellitus in Practice, Vivian Fonseca, MD, reviews current data on their efficacy and safety. In addition, he provides practical information on dosing and side effect management and considers where they might fit into the current armamentarium for the treatment of T2DM.

Insights into Managing Leukemia & MDS Edition
iPhone iPad

Chapter 1 - Overview of Leukemia
Last Reviewed: July 30, 2010


Chapter 2 - Lymphoid Leukemia
Last Reviewed: July 30, 2010


Chapter 3 - Myeloid Leukemia
Last Reviewed: July 30, 2010


Chapter 4 - Myelodysplastic Syndromes
Last Reviewed: September 01, 2010

Parkinson's Disease Edition: Early Diagnosis
and Management Edition
iPhone iPad

Chapter 1 - Parkinson's Disease: The Importance of
Early Diagnosis
Last Reviewed: Last Updated: June 15, 2010


Chapter 2 - Clinical Trial Design in Parkinson's Disease
Release date: May 17, 2010


Chapter 3 - MAO-B Inhibitors in Parkinson's Disease:
Evaluating the Evidence for
Neuroprotection
Release date: July 07, 2010


Multiple Sclerosis 2010 Edition
iPhone iPad

Chapter 1 - Multiple Sclerosis Basics
Last Reviewed: Month Day, Year


Chapter 2 - MRI and New Imaging Technologies in
Multiple Sclerosis
Last Reviewed: Month Day, Year


Chapter 3 - Currently Available Treatments for
Multiple Sclerosis
Last Reviewed: Month Day, Year


Chapter 4 - Small-Molecule Treatments in
Development for Multiple Sclerosis
Last Reviewed: Month Day, Year


Chapter 5 - Monoclonal Antibodies in Development
for Multiple Sclerosis
Last Reviewed: Month Day, Year


Chapter 6 - Managing Symptoms in Multiple Sclerosis
Last Reviewed: Month Day, Year

Update to the Tumor Immunology and
Immunotherapy: Metastatic Melanoma Edition

Chapter 1 - Immunology in Review
Last Reviewed: Month Day, Year


Chapter 2 - Tumor-Fighting T-Cells
Last Reviewed: Month Day, Year


Chapter 3 - Costimulation and the T-Cell Response
Last Reviewed: Month Day, Year


Chapter 4 - Targeting Immune Stimulation:
Clinical Application of Immunology
Last Reviewed: Month Day, Year


Chapter 5 - Autoimmune Effects of
CTLA-4 Antibodies: Management and
Correlation with Benefit

Last Reviewed: Month Day, Year


Chapter 6 - New and Emerging Agents in the
Treatment of Metastatic Melanoma

Last Reviewed: Month Day, Year


Women's Cancers Edition

Chapter 1 - Chemotherapy in Recurrent or
Metastatic Cervical Cancer
Last Reviewed: Month Day, Year


Chapter 2 - Current Management of
Endometrial Cancer
Last Reviewed: Month Day, Year


Chapter 3 - Frontline Management of
Ovarian Cancer
Last Reviewed: Month Day, Year


Chapter 4 - Recurrent Ovarian Cancer:
State of the State
Last Reviewed: Month Day, Year


Chapter 5 - Early Breast Cancer—
Tumor Genetic Profiling in
The 21st Century

Last Reviewed: Month Day, Year


Chapter 6 - Targeted Agents and Chemotherapy
Options for HER2-Positive and
HER2-Negative Metastatic Breast Cancer

Last Reviewed: Month Day, Year

Fracture Prevention and
Therapeutic Management Edition

Chapter 1 - Overview of Osteoporosis
Last Reviewed: Month Day, Year


Chapter 2 - Identifying Patients at Risk for
Osteoporosis and Fractures
Last Reviewed: Month Day, Year


Chapter 3 - Assessment of Fracture Risk Using FRAX®
Last Reviewed: Month Day, Year


Chapter 4 - Treatment of Osteoporosis
Last Reviewed: Month Day, Year


Chapter 5 - Management of the Postfracture Patient
Last Reviewed: Month Day, Year


Chapter 6 - Monitoring
Last Reviewed: Month Day, Year